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talk to the frog / General chat / Scientists cure CANCER and it gets no media...
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KittenClaw22
Member
4924 posts4924 posts
# Posted: 18 Jul 2007 02:28 · Edited by: KittenClaw22


Cheap, 'safe' drug kills most cancers
http://www.newscientist.com/article/dn10971-cheap- safe-drug-kills-most-cancers.html

A second article:

Scientists cure cancer, but no one takes notice
http://media.www.studentprintz.com/media/storage/p aper974/news/2007/01/23/Opinion/Scientists.Cure.Ca ncer.But.No.One.Takes.Notice-2667600.shtml

http://www.depmed.ualberta.ca/dca/

Scientists may have cured cancer.

Yep.

So, why haven't the media picked up on it?

Here's the deal. Researchers at the University of Alberta in Edmonton, Canada found a cheap and easy to produce drug that kills almost all cancers. The drug is dichloroacetate, and since it is already used to treat metabolic disorders, we know it should be no problem to use it for other purposes.

Doesn't this sound like the kind of news you see on the front page of every paper?

The drug also has no patent, which means it could be produced for bargain basement prices in comparison to what drug companies research and develop.

Scientists tested DCA on human cells cultured outside the body where it killed lung, breast and brain cancer cells, but left healthy cells alone. Rats plump with tumors shrank when they were fed water supplemented with DCA.

Again, this seems like it should be at the top of the nightly news, right?

Cancer cells don't use the little power stations found in most human cells - the mitochondria. Instead, they use glycolysis, which is less effective and more wasteful.

Doctors have long believed the reason for this is because the mitochondria were damaged somehow. But, it turns out the mitochondria were just dormant, and DCA starts them back up again.

The side effect of this is it also reactivates a process called apoptosis. You see, mitochondria contain an all-too-important self-destruct button that can't be pressed in cancer cells. Without it, tumors grow larger as cells refuse to be extinguished. Fully functioning mitochondria, thanks to DCA, can once again die.

With glycolysis turned off, the body produces less lactic acid, so the bad tissue around cancer cells doesn't break down and seed new tumors.

Here's the big catch. Pharmaceutical companies probably won't invest in research into DCA because they won't profit from it. It's easy to make, unpatented and could be added to drinking water. Imagine, Gatorade with cancer control.

So, the groundwork will have to be done at universities and independently funded laboratories. But, how are they supposed to drum up support if the media aren't even talking about it?

A letter from the researchers: http://www.depmed.ualberta.ca/dca/

Dear Friends,

We continue to be moved by your sustained interest and support of our efforts. We have been working tirelessly over the past several months to bring this research from the laboratory to the level of a clinical trial. This is a very challenging endeavor since it is not supported by the pharmaceutical industry. The process of bringing a drug from animal research to clinical trial takes a few years. However over the past 3 months, we have made significant progress towards achieving our goals. We have received help and input from stakeholders, medical and otherwise, and have received input from our health care partners in Alberta to ensure a clinical trial that can address both efficacy and safety of this potential treatment. We have significantly revised and improved our original protocol for Health Canada's consideration. We would like to remind you that despite the fact that dichloroacetate has been used in humans for over 20 years the appropriate dose for cancer patients remains unknown. There are several unique features of a cancer patient, from body metabolism to a number of unique drugs that only cancer patients are exposed to, that do not allow extrapolations from other conditions. Therefore, extra caution has to be exercised regarding the strategy to identify an optimal dose.

More importantly, we would like to remind you that this work, at least at its early stages, will not be able to be completed without your ongoing support.

Finally, we are very pleased to see that a number of key findings in scientific literature have surfaced over the past six months and appear to support a proposed theory and the potential effectiveness of dichloroacetate or similar drugs as effective therapies for cancer. Prestigious institutions and journals are now putting our work in context with these new developments and have expressed guarded optimism for these efforts. Such a review was recently published at the prestigious journal "Science" with a title "Metabolic Targeting as an Anti-cancer Strategy; Dawn of a New Era?" A copy of this paper can be found in the media section of our website.

Sincerely yours,

Evangelos D. Michelakis, MD, FACC, FAHA
Associate Professor of Medicine (Cardiology)
Director, Pulmonary Hypertension Program
Canada Research Chair in Pulmonary Hypertension


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Purple Pog
Member
324 posts
324 posts

# Posted: 18 Jul 2007 03:04


Isn't that lovely?


Stacy
Brunok9
Member
333 posts
333 posts

# Posted: 18 Jul 2007 03:16 · Edited by: Brunok9


Wow..Did they figure out that it is a for sure cure, though?


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Dakhota
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# Posted: 18 Jul 2007 03:49


I live in Alberta and this was big news back a while ago. Funny though, I don't really remember any follow-up . . . .


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bwebb
Member
475 posts
475 posts

# Posted: 18 Jul 2007 05:59


This is very interesting. I have done a little research and there are people out there trying this as a last resort for terminal cancer. The reason no pharmaceutical company wants to go through FDA approval is because there is no patent for it. This means that a company will spend at minimum 800 million dollars to put it through FDA testing just to have everyone start selling it when they are done which means they will lose close to a billion dollars. The only way this will get through is if the gov't foots the bill. There are many therapies that show promise in a petri dish or rat but have disappointing results in a human. Nonetheless, people can still use it even without FDA approval, and I for one find it very intriguing.

MegophryidaeMan
Member
2535 posts
2535 posts

# Posted: 18 Jul 2007 06:22


I love it when bwebb responds. You are always so knowledgable! Thanks for your contribution


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KittenClaw22
Member
4924 posts4924 posts
# Posted: 18 Jul 2007 16:14


Well the drug is already approved for other use by the FDA, it just needs to be approved for THIS use. Which wouldn't be such an expensive process.

No one wants to foot the bill though because they can't charge the outrageous fees most drug companies charge before the patent wears off. So realizing that they will have to get it approved and then compete with other generic brand prices means no one wants to do it.

It's just amazing to me that millions go into funding cancer research every year and this got no media coverage in the United States. This is HUGE. It should be on the front of every newspaper and on every news channel.


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ravencelt
Moderator
3436 posts3436 posts
# Posted: 18 Jul 2007 22:18


I love it when bwebb responds

LOL I was thinking the same thing! As soon as Kitten brough up mitochondria, haha.


[There] [They're] [Their]
And tomorrow we'll learn to tie our shoes.
bwebb
Member
475 posts
475 posts

# Posted: 18 Jul 2007 23:35


There are a multitude of types of cancers and variations of each one, which means this drug would have to be tested on each one to determine the dose loads and methods of administration that would be acceptable. Even though it is FDA approved for use with certain metabolic disorders it must be tested on cancers before it can be approved for this use, which is expensive. On another note, if the media hyped every single drug that killed cancer in a dish or in a rat you would be hearing about miracle cures every week. The fact is that the process of human testing is painfully slow because as soon as some side effect comes out everyone and their brother jumps on the lawsuit bandwagon. I hope it gets more attention though, and I am planning on inquiring about it when I start grad school.

Steven Busch
Member
1089 posts
1089 posts

# Posted: 19 Jul 2007 16:09 · Edited by: Steven Busch


Nothing comes without side effects.

http://www.buydca.com/Typical_side_effects_of_DCA_ in_animals.html


The following is extracted from "90-Day Toxicity Study of Dichloroacetate in Dogs"

Low dose was 12.5 mg/kg/day. Medium dose was 39.5 mg/kg/day. High dose was 75 mg/kg/day

Adverse effects noted in the low-dose group (12.5 mg/kg-day) included:
1. testicular degeneration
2. mild to moderate hepatic vacuolization in males and females
3. mild vacuolization of the myelinated white tracts of the cerebrum and cerebellum in males

http://www.highlighthealth.com/health-news/dichlor oacetate-not-ready-for-therapeutic-use/


Steve Busch
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Jennifer
Member
1522 posts
1522 posts

# Posted: 19 Jul 2007 23:57


That sounds pretty awful. Forgetting even about the mild side effects for which you wouldn't want to sue, you might really end up pretty bad off with not much of a life.

It might be okay if you were certain that you would otherwise die. What's a little hole in the head compared to death?


FrogPrincess
Steven Busch
Member
1089 posts
1089 posts

# Posted: 20 Jul 2007 00:45


What profits a man to gain his life but lose his testicles!!!!!!!!!!!!!!

My Father is undergoing radiation for esophageal cancer and a good friend just had surgery for lung cancer and starting a new drug to slow what could not be removed. We would all like a cure.


Steve Busch
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bwebb
Member
475 posts
475 posts

# Posted: 20 Jul 2007 02:01


I can attest that progress in this field is being made in leaps and bounds, but there are many types of cancer and most need unique cures. It is a tough battle but there are many very smart dedicated people who are working to win the battle. Science feeds off of itself and this is no exception.

cherisse
Member
1536 posts
1536 posts

# Posted: 20 Jul 2007 02:49 · Edited by: cherisse


im actually hoping that they dont find a cure for cancer, or any other disease for that matter.
DONT GET ME WRONG, the thought of millions of people dying horrible painful deaths is very sad and disturbing, but, if they did in fact cure such a disease like cancer, could you imagine how overpopulated our world would be? and if they cured AIDS?
the world has set up its system of checks and balances, and that includes diseases that are, even if you dot agree with me, helping to keep our population somewhat in check.
take my response however you want, but this is just my opinion. everyone in my family that has died so far, has died from some form of cancer i.e throat, lung, spinal. and i doubt it will stop with me or my children.My youngest cousin on my mothers side is 11, and is battling HIV/Aids. so i do have experience with these diseases, not first hand, but im not basing my opinion on ignorance.


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Brunok9
Member
333 posts
333 posts

# Posted: 20 Jul 2007 02:55


I not sure how overpolluated we would be. I don't want to be negative or cynical, but we are our own worst enemy...we kill eachother every day. There would be alot more people if we didn't. Just look at how many people are lost during war...It's very sad, but true.


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cherisse
Member
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1536 posts

# Posted: 20 Jul 2007 02:57


true, i didnt mean for it to sound as if these diseases are the only thing that are holding us back from overpopulation.


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Brunok9
Member
333 posts
333 posts

# Posted: 20 Jul 2007 03:03


Oh, you didn't. I kinda think you're right, too. I hate to think of all of those suffering with cancer, though..kinda makes you think which would be better for people..


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Jennifer
Member
1522 posts
1522 posts

# Posted: 20 Jul 2007 03:04


I'm going to hope that Steve's father and his good friend recover even if they have something to do with overpopulation.

And it's not enough progress if they don't.


FrogPrincess
Steven Busch
Member
1089 posts
1089 posts

# Posted: 20 Jul 2007 04:48


Birthcontrol is the key to population control. From what I hear high fructose corn syrup is going to be the big killer of the future. Obesity...this is to be the first generation that will NOT outliving their parents.

Jennifer..thank you for your comments about my friend and Father. My Father has lived a long and full life...84 1/2 years. We debated the radiation treatments but decided it would improve his quality of life for his remaining time. Our friend, on the other hand, is not done with life and not ready to go. It would be a shame to lose him.


Steve Busch
Yoncalla Frog
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cherisse
Member
1536 posts
1536 posts

# Posted: 20 Jul 2007 05:00


"birth control is the key to overpopulation control."

AGREED!

this may sound weird to many people, and i have been accused of being gay, and lying about it, but i am a "type A sexual" person. i do not believe in sex, having children, or getting married. the latter two having nothing to do with being "A sexual". just something i am STRONGLY against.

so many people complain about not having enough of anything to take care of their kids, but if they just keep it in their pants, then there would be nothing to worry about.


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spawn
Member
2553 posts
2553 posts

# Posted: 20 Jul 2007 05:07


Type A? What other types are there? Is there a guide or book on this material? It sounds intriguing.

cherisse
Member
1536 posts
1536 posts

# Posted: 20 Jul 2007 05:20


as far as i know there is no categorization of all sexual preferences, i do know, however, that there has not been very much research done on this, and the doctors who have studied it had classified us as "type A".

CNN or ABC did a story on A Sexual people a few years back. VERY interesting.


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Frogbert
Moderator
2424 posts
2424 posts

# Posted: 20 Jul 2007 05:27


http://en.wikipedia.org/wiki/Asexuality


"Lead a life of purpose, Kindness being the first." ME

"The life of the individual has meaning only in so far as it aids in the making the life of every living thing nobeler and more beautiful" Albert Einstein
cherisse
Member
1536 posts
1536 posts

# Posted: 20 Jul 2007 05:33


thank you, Frogbert.


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Jennifer
Member
1522 posts
1522 posts

# Posted: 20 Jul 2007 05:35 · Edited by: Jennifer


Frogbert, you missed the differences amongst the asexuals, the bsexuals and the csexuals.

Hmmm, that link I put in at first (it was about "asexuals, bsexuals, and csexuals) was a little too risque on closer read. But Spawn, Google "bsexual" (at least for a laugh).


FrogPrincess
cherisse
Member
1536 posts
1536 posts

# Posted: 20 Jul 2007 06:09


that was funny,
even though im not sure if you were posting that to be funny, or just making fun of what i believe.


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Jennifer
Member
1522 posts
1522 posts

# Posted: 20 Jul 2007 06:13 · Edited by: Jennifer


The beliefs re: sexuality are not something I would humor.

The way you expressed it however-- (and Spawn's comment on it) -- was ... priceless.


FrogPrincess
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